Neoprene was invented by DuPont scientists on 17^th April 1930^[2] after Dr. Elmer K. Bolton of DuPont laboratories attended a lecture by Fr. Julius Arthur Nieuwland, a professor of chemistry at the University of Notre Dame. Fr. Nieuwland's research was focused on acetylene chemistry and during the course of his work he produced divinyl acetylene, a jelly which firms into an elastic compound similar to rubber when passed over sulfur dichloride. After DuPont purchased the patent rights from the university, Wallace Carothers of DuPont took over commercial development of Nieuwland's discovery in collaboration with Nieuwland himself. DuPont focused on monovinyl acetylene and reacted the substance with hydrogen chloride gas, manufacturing chloroprene.

Neoprene, which was originally called duprene, was the first mass-produced general-purpose synthetic rubber.